Fire and Rescue NSW (FRNSW) has contained and rendered safe a large chemical spill after a fatal truck crash on the Sturt Highway in Euston in the state's Murray Region.

All emergency services responded to reports of a crash between two trucks around 5:30pm on Wednesday, April 9.

One driver had self evacuated.

Unfortunately, the other driver was killed in the crash.

The crash caused a large spill of hazardous chemicals onto the roadway.

On arrival, FRNSW firefighters established an exclusion zone and created bunding to contain the spillage.

FRNSW firefighters, wearing chemical protective clothing, entered the hazard zone to identify the chemicals and size of the spill.

In consultation with the NSW Environmental Protection Agency (EPA), a hazardous material recovery plan was developed and implemented by FRNSW with the support of all other emergency services, including the Rural Fire Service (RFS), NSW Ambulance, NSW Police,

Victoria's Country Fire Authority (CFA), and the EPA.

FRNSW rendered the site safe of the hazardous chemicals just after 10 last night, almost 30 hours after the incident occurred.

The site was handed over to Transport for NSW, which oversaw the salvage and recovery of the vehicles.

FRNSW Superintendent, Adam Dewberry, stated incidents like this are extremely complex.

"Unfortunately, this incident was fatal, involving a large hazardous material spill and the recovery of two heavy vehicles in a remote location," Supt. Dewberry added.

"The recovery efforts are a credit to all attending emergency services, which worked efficiently and collaboratively throughout this incident."