Two people have died following an underground explosion at a mine in Far Western NSW during the early hours of this morning, sending shockwaves through the tight-knit regional community.

Emergency services were called to the mine on Endeavour Mine Road at Cobar, approximately 450 kilometres east of Broken Hill, at 3.45am on Tuesday after reports of a critical workplace incident.

Officers from Central North Police District arrived at the scene to be told a man had been confirmed dead following the underground explosion.

Two women were brought to the surface by emergency crews, however one woman has since succumbed to her injuries. A second woman was airlifted to hospital, where she is being treated for hearing damage and shock.

Emergency services remained at the scene throughout the morning as investigations into the cause of the explosion commenced.

Police will prepare a report for the Coroner, while SafeWork NSW has launched an investigation into the incident.

The tragedy has rocked the mining community of Cobar, a town of approximately 4,000 residents where the mining industry forms the backbone of the local economy.

Cobar has a long history of mining dating back to the 1870s, with copper, gold, zinc, lead and silver extracted from the region's rich mineral deposits.

Endeavor is a major underground silver, zinc and lead mine.

It is located 40 kilometres north of Cobar, owned by Polymetals.

The mine has operated since the early 1980s but Polymetals bought the operation in 2023 with the aim of restarting mining activities this year.

Emergency services are still at the scene.

NSW Police will prepare a report for the coroner and assist SafeWork NSW with its investigation.

Authorities have urged anyone with information about the incident to contact Crime Stoppers on 1800 333 000 or via the website at nsw.crimestoppers.com.au. Information is treated confidentially.

The public has been reminded not to report information via NSW Police social media pages.

The identities of the deceased have not been released pending notification of next of kin.